Lenvatinib 4mg capsules | Lenvatinib | Millionpharma
DESCRIPTION
 |
| Lenvatinib 4mg |
Lenvatinib 4mg
is a multi-kinase inhibitor and antineoplastic agents. It is a type of targeted
treatment which target the specific cancer cells and hence reduces side effects
caused by affected cells.
Lenvatinib 4mg
inhibits the protein which promotes cell division by preventing the cancer cell
development.
PRESCRIBED
FOR
In adult, Lenvatinib
4mg tablet is indicated for the treatment
of metastatic, progressive, radioactive Differentiated Thyroid cancer.
Lenvatinib 4mg
in combination with everolimus is indicated in patients for the treatment of
advance Renal Cell Carcinoma following treatment before anti-angiogenic
therapy.
Lenvatinib 4mg
is also indicated for the first line treatment in patients suffering with
unresectable hepatocellular carcinoma.
MECHANISM
OF ACTION
Lenvatinib
is a tyrosine kinase inhibitor which has shown mainly anti-angiogenic
properties, and direct prevention of malignant developed was also observed
inside the models. Lenvatinib which selectively prevents the kinase functions
of vascular endothelial growth factor receptors 1(FLT1), 2 (KDR), 3 (FLT4).
Although not been studied directly
with Lenvatinib,
the mechanism of action (MOA) for High blood pressure is hypothesizing to be
resolve by the prevention of VEGFR2 in vascular endothelial cells.
Same as the, the action for
proteinuria is hypothesizing to be interfere with down regulation of VEGFR1 and
VEGFR2 in the cell of bowman’s capsules of the glomerulus.
PROPERTIES
Ingredients : Lenvatinib
Strength : 4mg
Package : Pack of 20 Capsules
ADD
ME
Absorption:
Time to high plasma concentration is
1-4 hours post dose. Effect with food is low to the extent Lenvatinib
4mg of absorption.
Distribution:
bounding of Human plasma proteins is
98% to 99%.
Metabolism:
Lenvatinib 4mg is primarily metabolized in CYP3A. Lenvatinib
4mg metabolic pathway is identified as
enzymatic and non-enzymatic processes.
Elimination:
eliminated via 64% feces and 25%
urine.
DOSAGE
MANAGEMENT
 |
| Lenvatinib 4mg |
- The usual dose of Lenvatinib
for the adult patients is 24mg and administer has two 10mg capsules and
one 4mg capsule given orally, once daily taken with or without food.
- The Lenvatinib tablet should continue until disease
progression or until unacceptable toxicity occurs.
- Take Lenvatinib tablet at the same time.
- Patients with severe renal or hepatic impairment the
dose is 14mg administer once daily orally.
OVERDOSE:
Lenvatinib is not expected to be
dialyzable because of maximum plasma protein binding and if the dose getting of
Lenvatinib 4mg
orally then causes death due to multiorgan dysfunction occurred in the
patients.
Inform doctor if you have or had
seizures, hypertension, a stroke, a heart attack, , especially those due to
blood clots, a fistula, a tear in the wall of your GIT, QT interval
prolongation (an irregular heart rhythm that can lead to fainting, loss of
consciousness, seizures, or sudden death), low levels of Ca, K or Mg in your
blood, bleeding problems, or cardiac, renal, or hepatic disease.
Take into the knowledge that Lenvatinib
4mg may reduce the fertility in men and women. It not means that you or
your partner cannot become pregnant. Inform doctor before if you are pregnant
or plan to become pregnant. After becoming pregnant, you should use birth
control while treatment with Lenvatinib 4mg and for at least 2 weeks
after your treatment, become pregnant during Lenvatinib therapy, call your
doctor immediately. Lenvatinib
4mg may harm the fetus.
Inform the doctor if you are
breastfeeding or plan to breastfeed. Avoid breastfeed during Lenvatinib
4mg treatment
PRECAUTIONS
 |
| Lenvatinib 4mg |
›
Blood pressure may increase while
treatment with Lenvatinib
4mg tablet.
Your doctor will preferably check your blood pressure during your treatment.
›
Inform the doctor if you are
allergic to Lenvatinib 4mg, any other regimens, or any of the
ingredients in Lenvatinib
4mg capsules.
›
Other prescription and
nonprescription medications, vitamins, nutritional supplements, and herbal
products you are taking or plan to take. Your doctor may to change the doses of
your drugs or guide carefully for adverse reaction.
SIDE
EFFECTS
Common side effects:
- Tiredness
- Peeling of skin on palms and sole of the feet
- Constipation
- Loss of appetite
- Weight loss
- Joint and muscle pain
- Insomnia.
Serious side effects :
- Shortness of breath
- Chest pain
- Pain in arm, back, neck or jaw
- Seizures
- Black, tarry or bloody stools
- Heavy menstrual bleeding
- Coughing up blood
- Yellowing of the skin or eyes.
PREGNANCY
When administrated to pregnant, Lenvatinib
4mg drugs can cause harm to the fetal.
There are no available human data related to drug associated risk. Advice
pregnant women specific risk to fetus.
LACTATION
Excretion in human milk is unknown.
It’s not known that drug is present in human milk Because of the serious side
effects in infants from the drug, Advice to avoid breast feeding during
treatment with Lenvatinib 4mg.
STORAGE
Store at 25°C
Keep out of the children hands
Discard the after-expiry date Dispense the drug only in original container
KEYWORDS:
Lenvatinib 4mg capsules, Lenvatinib 4mg, Lenvatinib, Lenvima
CONTACT
US
PHONE NO: +91-9940472902
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